Understanding the Differences: Fluticasone Propionate vs Fluticasone Furoate

Mack Johnson
8 Min Read
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Fluticasone propionate and fluticasone furoate take center stage as prescribed corticosteroids. While their uses overlap, healthcare providers and patients alike must grasp their differences.

This document aims to shed light on their unique properties, and applications. We will also discuss potential side effects. Let’s demystify the difference between fluticasone propionate vs fluticasone furoate in respiratory care.

Let’s dive in!

Onset of Action

Fluticasone propionate is a synthetic corticosteroid with potent anti-inflammatory effects. Its effect starts working within 24 hours of administration. It acts by reducing inflammation in the airways. This improves breathing and decreases symptoms of respiratory conditions. Common conditions include asthma and COPD.

Fluticasone furoate has a longer onset of action, taking 24 to 48 hours to start working. This is due to its added ester group. It slows down its metabolism and allows for sustained release in the body.

Duration of Action

The duration of action is another factor to consider when comparing these medications. Fluticasone propionate has a shorter duration of action. Thus requiring many dosages for optimal effectiveness.

Fluticasone furoate has a longer duration of action, allowing for a single dose. This makes it a convenient option for patients who need to follow a medication schedule.

Dosage Forms

Fluticasone Propionate is available in several forms. The inhaler medication form often requires a dose twice daily, morning and evening. The nasal spray is used once daily to control symptoms of allergic rhinitis. The different forms include the following:

  • aerosol inhalers
  • nasal sprays
  • topical creams or ointments

Fluticasone Furoate is available as a nasal spray and as an inhalation powder. The nasal spray is usually used once daily. It is used for the treatment of symptoms associated with seasonal and perennial allergies. The inhalation powder, part of a therapy for COPD and asthma, is also administered once daily.

The choice between fluticasone propionate vs fluticasone furoate depends on the condition treated. It is also dependent on patient preference and convenience. It also includes the patient’s ability to adhere to the drug dosage schedule.


Fluticasone propionate is effective in managing the symptoms of allergic rhinitis. This includes sneezing, itchy or runny nose, and watery eyes.

Fluticasone furoate is most beneficial in relieving severe asthma and nasal polyps. In combination with vilanterol, it is also employed to treat certain symptoms of COPD. This includes shortness of breath and wheezing.

Age Applicability

Another key difference lies in their age applicability. Fluticasone propionate is prescribed to children as young as four years old.

Fluticasone furoate is generally recommended for adults and older children. Targeting individuals aged twelve years and above.

This distinction ensures that the appropriate medication is administered to different age groups. It catered to their specific needs and ensured optimal efficacy and safety.

Side Effects

There is a risk of side effects when using fluticasone propionate or furoate. It’s worth noting that these side effects are mild. It should subside as the body adjusts to the medication.

Common side effects of fluticasone propionate include:

  • Throat irritation or soreness
  • Hoarseness or change in voice
  • Nosebleeds
  • Cough
  • Headaches
  • Nausea

In contrast, fluticasone furoate may produce comparable side effects. It is additionally linked to:

  • Sinus pain
  • Sores or white patches inside the mouth or on the lips
  • Difficulty breathing
  • Vision changes, such as blurred vision

Patients should seek immediate medical attention if they experience severe side effects. Remember that there are reasons why your healthcare provider has prescribed these medications. It’s because they believe the benefits outweigh the potential risks. Always communicate any concerns or unusual side effects to your healthcare provider immediately.


The cost of these medications can vary based on several factors. It includes the dosage form and the location where to buy. It also includes insurance coverage and any available manufacturer coupons.

The cost of Fluticasone Propionate can vary between $10 and $50 for a 10-gram supply. This will depend on the pharmacy you choose. These prices are applicable only for customers paying in cash. It can’t be used in conjunction with insurance plans.

Notable brands of fluticasone propionate include Flovent, Flixotide, and Cutivate. If you’re looking to get Flovent cheaper or any other brands, be sure to explore the available coupons.

Fluticasone Furoate tends to be more expensive, with prices ranging from about $30 to $60 for a supply of 10 grams. These prices apply to cash-paying customers and may not be valid with insurance plans. Common brands of Fluticasone Furoate include Arnuity Ellipta and Avamys.

Keep in mind that these costs are approximate and subject to change. It’s always best to check with your local pharmacy or insurance provider. It ensures you have up-to-date information on medication costs.

Drug Interactions

Fluticasone propionate and fluticasone furoate may interact with other medications. It is another important aspect to consider. Fluticasone propionate may interact with ritonavir and atazanavir. Both of which are antiviral medications.

It may also interact with certain antifungal drugs such as ketoconazole. These interactions can increase the levels of fluticasone propionate in the body. This can lead to more side effects.

Fluticasone furoate may interact with other drugs metabolized through the CYP3A4 enzyme pathway. This can include certain anti-HIV medications and antifungal drugs. These interactions can increase the amount of fluticasone furoate in the body. This can also increase the risk of side effects.


Fluticasone furoate and fluticasone propionate benefits include the management of respiratory conditions. By reducing airway inflammation, these medications can improve breathing and reduce symptoms. It can also prevent exacerbations of conditions such as asthma and COPD.

Both drugs have a low risk of side effects compared to other corticosteroids. This makes them a popular choice among healthcare providers and patients alike.

Understanding the Difference Between Fluticasone Propionate vs Fluticasone Furoate

Fluticasone propionate and fluticasone furoate are potent corticosteroids used in respiratory care. Propionate has faster action and diverse forms. Furoate offers single dosing and sustained effectiveness. The choice between fluticasone propionate vs fluticasone furoate depends on factors. This can include factors like condition, preference, side effects, and cost.

Open dialogue with healthcare providers is key to a suitable treatment plan.

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Meet Mack, a dynamic and insightful tech and general niche blogger whose passion for innovation and curiosity about the world drive their writing. With a keen eye for emerging technologies and a knack for breaking down complex topics into accessible and engaging content, Mack has become a trusted voice in the online space.